Estrogen Receptor Analyte ControlDR


Estrogen Receptor Analyte ControlDR

Estrogen receptor (ER) has long been a target for treatment in breast cancer, with the greatest impact occurring with the introduction of Tamoxifen. Tamoxifen is a selective ER modulator (SERM) as it binds to ER causing dimerization yet does not induce the same recruitment of co-activators as the estrogens do. Newer therapies such as the aromatase inhibitors (AI) have demonstrated a greater effectiveness in both the adjuvant and metastatic setting.

Assessment for ER by IHC has to be optimised and run at an appropriate sensitivity. Estrogen Receptor Analyte ControlDR contains four cores, offering a full range of expression for ER: negative, low, medium, and high.


  • Cells are fixed in 10% neutral buffered formalin and paraffin wax embedded.
  • Pre-cut sections are cut at 4µm, mounted on positively charged slides and baked overnight at 37°C.
  • Cell microarrays (CMA) contain cores that are 2mm in diameter and 3-3.5mm in length. It is possible to obtain over 300-400 sections depending on thickness.


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Estrogen Receptor Analyte ControlDR